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Myeloid-Derived Suppressor Cells and Cancer (eBook) von David Escors

Myeloid-Derived Suppressor Cells and Cancer
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Springer International Publishing
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53,49 €* eBook

ISBN-13:
9783319268217
Veröffentl:
2016
Einband:
eBook
Seiten:
102
Autor:
David Escors
Serie:
SpringerBriefs in Immunology
eBook Format:
PDF
eBook-Typ:
Reflowable eBook
Kopierschutz:
Digital Watermark [Social-DRM]
Sprache:
Englisch
Systemvoraussetzungen
Inhaltsverzeichnis

Controversies in Neoplastic Myeloplasia.- Differentiation of Murine Myeloid-derived Suppressor Cells.- Human MDSCs.- Ex Vivo MDSC Differentiation Models.- Immunoregulatory myeloid cells in the tumor microenvironment.- Signal Transducer and Activation of Transcription 3: A Master Regulator of Myeloid-derived Suppressor Cells.- Future Perspectives.

Beschreibung
The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.

 

Schlagwörter zu:

Myeloid-Derived Suppressor Cells and Cancer von David Escors - mit der ISBN: 9783319268217

Ex vivo MDSC Differentiation; Human and Mouse MDSCs; Murine MDSC Differentiation; Myeloid-Derived Suppressor Cells (MDSCs); STAT3 Pathway; Therapeutic Targeting; C; Immunology; Cell Biology; Oncology; Cancer Biology; Biomedical and Life Sciences, Online-Buchhandlung

 

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