Concepts in Vaccine Development () von Stefan H. E. Kaufmann

Frontmatter -- Preface -- Bicentennial of the first vaccination by Edward Jenner -- Contents -- 1. The Need for New Vaccines -- 1.1. Vaccines as Evolutionary Tools: The Virulence-Antigen Strategy -- 1.2. Economic Perspectives on Vaccine Needs -- 1.3. Future Immunization Strategies Considerations from the Public Health View -- 1.4. The New Pertussis Vaccines -- 2. General Principles of Immunology -- 2.1. Basic Principles of Immunity Against Intracellular Bacteria and Protozoa -- 2.2. Viral Immunity and Vaccine Strategies -- 2.3. Broadly Reactive HLA Restricted Cell Epitopes and Their Implications for Vaccine Design -- 2.4. Quantitative Considerations in the Design of Vaccination Strategies Against Pathogens Uniquely Susceptible to Cell-Mediated Attack -- 2.5. The Impact of the Type 1 and Type 2 Helper Cell Concept on Novel Vaccine Design with Emphasis on Protection Against Leishmania Parasites -- 3. General Principles of Vaccinology -- 3.1. Modern Adjuvants. Functional Aspects -- 3.2. Biodegradable Microspheres as Vehicles for Antigens -- 3.3. Peptide Based Vaccines -- 3.4. Recombinant Bacteria as Vaccine Carriers of Heterologous Antigens -- 3.5. Genetic Detoxification of Bacterial Toxins -- 3.6. Recombinant Virus as Vaccination Carrier of Heterologous Antigens -- 3.7. Naked DNA Vaccination -- 3.8. Oral Vaccination, Mucosal Immunity and Oral Tolerance with Special Reference to Cholera Toxin -- 4. Specific Vaccination Strategies -- 4.1. Helicobacter pylori: Pathogenic Determinants and Strategies for Vaccine Design -- 4.2. Malaria Vaccination -- 4.3. Vaccination Against Schistosomiasis: Concepts and Strategies -- 4.4. AIDS Vaccination -- 4.5. Vaccination Therapy Against Autoimmune Diseases -- Contributors -- Index