Metal Ions in Bio-Imaging Techniques () von Astrid Sigel

Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes; in fact, it is an old wisdom that metals are indispensable for life. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in numerous interconnecting research fields.

Volume 22, entitledMetal Ions in Bio-Imaging Techniques, of the seriesMetal Ions in Life Sciences deals with metal ions as tools in imaging. This dates back to the first half of the past century, when barium sulfate was orally given to patients undergoing X-ray examination. The use of contrast agents has since developed into a large interdisciplinary field encompassing not only medicine, but also chemistry, material sciences, physics, biology, engineering, and computer sciences.MILS-22 provides deep and current insights in17 stimulating chapters on the new research frontiers of this fast growing field on bio-imaging ... and beyond. For example, adding bio-sensing yields theranostic agents, meaning diagnosis and therapy linked in the same molecule; ions of Gd, Mn, Fe, Co, Ir,^99mTc, etc., are involved. Other important topics are, e.g., metal complexes in paramagnetic Chemical Exchange Transfer (paraCEST), radiometals for Positron Emission Tomography (PET) imaging, or paramagnetic metal ion probes for¹⁹F magnetic resonance imaging.MILS-22 is written by57 internationally recognized experts from 12 countries, that is, from the US via Europe to China. The impact of this vibrant research area is manifested by more than2300 references and nearly120 figures, mostly in color, and several informative tables. To conclude,Metal Ions in Bio-Imaging Techniques is an essential resource for scientists working in the wide range from material sciences, enzymology, analytic, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that also excellent information for teaching is provided.

Astrid Sigel, Universtiy of Basel, Switzerland,Eva Freisinger andRoland K. O. Sigel, University of Zürich, Switzerland.