Metal-Carbon Bonds in Enzymes and Cofactors () von Astrid Sigel

Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes; in fact, it is an old wisdom that metals are indispensable for life. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in numerous interconnecting research fields.

From the Content:

Organometallic Chemistry of B12 Coenzymes
Cobalamin- and Corrinoid-Dependent Enzymes
Nickel-Alkyl Bond Formation in the Active Site of Methyl-Coenzyme M Reductase
Nickel-Carbon Bonds in Acetyl-Coenzyme A Synthases/Carbon Monoxide Dehydrogenases
Structure and Function of [NiFe]-Hydrogenases
Carbon Monoxide and Cyanide Ligands in the Active Site of [FeFe]-Hydrogenases
Carbon Monoxide as Intrinsic Ligand to Iron in the Active Site of [Fe]-Hydrogenase
The Dual Role of Heme as Cofactor and Substrate in the Biosynthesis of Carbon Monoxide
Copper-Carbon Bonds in Mechanistic and Structural Probing of Proteins as well as in Situations where Copper Is a Catalytic or Receptor Site
Interaction of Cyanide with Enzymes Containing Vanadium, Manganese, Non-Heme Iron, and Zinc
The Reaction Mechanism of the Molybdenum Hydroxylase Xanthine Oxidoreductase: Evidence Against the Formation of Intermediates Having Metal-Carbon Bonds
Computational Studies of Biooganometalllic Enzymes and Cofactors

The occurrence of a wide variety of metal-carbon bonds in living organisms, ranging from bacteria to humans, is only recently recognized. Of course, the historical examples are the B12 coenzymes containing cobalt-carbon bonds, but now such bonds are also known for nickel, iron, copper, and other transition metal ions. There is no other comparable book; MILS-6, written by 17 experts, summarizes the most recent insights into this fascinating topic.

HelmutundAstrid Sigel, University of Basel, Switzerland.Roland K. O. Sigel, University of Zürich, Switzerland.