Regenerative Medicine and Plastic Surgery (eBook) von Dominik Duscher

PART 1: SKIN AND SOFT TISSUE REGENERATION

1. Induction of the Fetal Scarless Phenotype in Adult Wounds: Impossible?

2. Scar Treatment and Prevention: Know Thine Enemy

3. Challenges and Opportunities in Drug Delivery and Wound Healing

4. Harvesting, Processing and Injection of Lipoaspirate for Soft Tissue Reconstruction - Details Make the Difference

5. Adipose Tissue Complex (ATC):  Cellular& Biocellular Uses of Stem/Stromal Cells& Matrix in Cosmetic Plastic, Reconstructive Surgery& Regenerative Medicine

6. Preparation, Characterization, and Clinical Implications of Human Decellularized Adipose Tissue Extracellular Matrix

7. Mesenchymal Cells that Support Human Skin Regeneration

8. Stem Cells and Burn

9. Skin Tissue Engineering Advances in Severe Burns: Review and Therapeutic Applications

10. Skin Substitutes for Burn Wounds

11. Wnt Signaling During Cutaneous Wound Healing

12. Drug Delivery Advances for the Regeneration of Aged Skin

PART 2: BONE REGENERATION

13. Innovative Scaffold Solution for Bone Regeneration Made of Beta-Tricalcium Phosphate Granules, Autologous Fibrin Fold and Peripheral Blood Stem Cells

14. Ordinary and Activated Bone Substitutes

15. Absorbable Bone Substitute Materials Based on Calcium Sulfate as Triggers for Osteoinduction and Osteoconduction

16. Perivascular Progenitor Cells for Bone Regeneration

17. Bone Repair and Regeneration is Regulated by the Wnt Signaling Pathway

PART 3: CARTILAGE REGENERATION

18. Cartilage Tissue Engineering: Role of Mesenchymal Stem Cells, Growth Factors and Scaffolds

19. Sox9 Potentiates BMP2-induced Chondrogenic Differentiation and Inhibits BMP2-induced Osteogenic Differentiation

20. Stem Cells and Ear Regeneration

PART 4: MUSCLE AND TENDON REGENERATION

21. Muscle Fiber Regeneration in Long Term Denervated Muscles. Basics and Clinical Perspectives

22. Rejuvenating Stem Cells to Restore Muscle Regeneration in Aging

23. Silk Fibroin-Decorin Engineered Biologics to Repair Musculofascial Defects

24. Skeletal Muscle Restoration Following Volumetric Muscle Loss: the Therapeutic Effects of a Biologic Surgical Mesh

25. Principles of Tendon Regeneration

26. Stem Cells and Tendon Regeneration

27. Cell Therapies for Tendon: Treatments and Regenerative Medicine

PART 5: NERVE REGENERATION

28. The present and future for peripheral nerve regeneration

29. The Regeneration of Peripheral Nerves Depends on Repair Schwann Cells

30. Adipose-derived Stem Cells (ASCs) for Peripheral Nerve Regeneration

31. Direct Reprogramming Somatic Cells into Functional Neurons: A New Approach to Engineering Neural Tissue in Vitro and in Vivo

The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspect of regenerative medicine; accordingly, the second part discusses the novel bone implants, activated bone grafts and bone tissue engineering. The books third part, focusing on cartilage regeneration, includes chapters on e.g. stem cells and ear regeneration. In turn, part four addresses muscle and tendon regeneration: from tendon to bone and tendon to muscle, as well as aging in the realm of muscle regeneration. Lastly, part five highlights nerve regeneration, deepening surgeons knowledge to help them successfully treat injuries to the peripheral neural system. 

Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties.

"With beautiful clinical images and artwork, this book will be a central companion to both practicing plastic surgeons who wish to remain abreast of oncoming technologic advances and regenerative medicine researchers who wish to understand the current state of the art of surgical reconstruction."
- Geoffrey C. Gurtner, MD, FACS
Johnson and Johnson Distinguished Professor of Surgery
Professor (by courtesy) of Bioengineering and Materials Science
Inaugural Vice Chairman of Surgery for Innovation
Stanford University School of Medicine

Dr. Dominik Duscher MD, PhD, is the director of the Division of Experimental Plastic Surgery at Technical University of Munich. He holds a doctorate of medicine and a research doctorate focusing on Stem Cell Biology and Regenerative Medicine. After his medical education in Vienna (Medical University of Vienna), London (University College London) and Boston (Harvard Medical School) he graduated from a postdoctoral fellowship in Stem Cell Biology and Regenerative Medicine at Stanford University. For his research he received the Stanford University biomaterial research prize, and scholarships from the American Austrian Foundation and the Austrian Science Fund, among other distinctions. Dr. Duscher holds multiple patents, published more than 100 peer reviewed publications and authored more than 100 conference presentations. Dominik Duscher is the General Secretary of the European Plastic Surgery Research Council. He further acts as the Research Coordinator of the Microsurgical Education Center of the Kepler University Hospital Linz and the Young Forum of the Austrian Society for Surgery of the Hand.