Human Oral Mucosa (E-Book) von Christopher Squier

1 The functions of oral mucosa 3

1.1 Oral mucosa: What is it and what does it do? 3

1.2 Functions of the oral mucosa 5

References 7

2 The organization of oral mucosa 9

2.1 Clinical features 10

2.2 Component tissues and glands 14

References 16

3 Oral epithelium 19

3.1 Histological structure of oral epithelium 20

3.2 Epithelial proliferation and turnover 24

3.3 Molecular and cellular organization of oral epithelium 29

3.4 Non-keratinocytes in the oral epithelium 41

References 50

4 The interface between epithelium and connective tissue 53

4.1 Organization of the normal interface 55

4.2 Immune-mediated subepithelial blistering diseases (IMSEBDS) 57

References 58

5 Connective tissue 59

5.1 Lamina propria 59

5.2 Blood supply 68

5.3 Nerve supply 70

References 74

6 Regional differences in the oral mucosa 77

6.1 Structural variations in different regions 77

6.2 Junctions in the oral mucosa 85

References 97

7 Development and aging of the oral mucosa 99

7.1 Developmental stages of oral mucosa 100

7.2 The control of mucosal development: epithelialmesenchymal interaction 104

7.3 Aging 106

References 109

8 Barrier functions of oral mucosa 113

8.1 The permeability barrier 114

8.2 Immunologic barrier function of oral mucosa 122

References 135

9 Homologies in structure and function among mucosae: oral, esophageal, and vaginal mucosa 145

9.1 Esophagus 145

9.2 Vagina 147

9.3 Organization of the tissues of esophagus and vagina 147

9.4 Non-keratinocytes in esophageal and vaginal mucosa 153

9.5 Infl ammatory cells 154

References 154

Index 159

The aim of the present volume is to provide a more sophisticated text on human oral mucosa than presently exists in textbooks and to bring together information that is otherwise to be found in separate, specialist volumes into a comprehensive text. It relates structure at the molecular, cellular and tissue level to function and to clinical behavior. The volume is directed to advanced students and researchers in oral biology, as well as those in allied areas of investigation, such as dermatology, gynecology, internal medicine and pathology.

Kim Brogden is a professor in the Department of Periodontics and the Dows Institute for Dental Research at the University of Iowa. His work on innate immunity in mucosal diseases including oral mucosa is recognized worldwide and he is the author of over 155 books, chapters or peer reviewed publications.