Neurodegenerative Diseases and Metal Ions, Volume 1 (E-Book) von Astrid Sigel

PREFACE TO VOLUME 1.

CONTRIBUTORS TO VOLUME 1.

TITLES OF VOLUMES 144 IN THEMETAL IONS IN BIOLOGICAL SYSTEMS SERIES.

CONTENTS OF VOLUMES IN THEMETAL IONS IN LIFE SCIENCES SERIES.

1THE ROLE OF METAL IONS IN NEUROLOGY. AN INTRODUCTION (Dorothea Strozyk and Ashley I. Bush).

2PROTEIN FOLDING, MISFOLDING, AND DISEASE (Jennifer C. Lee, Judy E. Kim, Ekaterina V. Pletneva, Jasmin Faraone-Mennella, Harry B. Gray, and Jay R. Winkler).

3METAL ION BINDING PROPERTIES OF PROTEINS RELATED TO NEURODEGENERATION (Henryk Kozlowski, Marek Luczkowski, Daniela Valensin, and Gianni Valensin).

4METALLIC PRIONS: MINING THE CORE OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES (David R. Brown).

5THE ROLE OF METAL IONS IN THE AMYLOID PRECURSOR PROTEIN AND IN ALZHEIMERS DISEASE (Thomas A. Bayer and Gerd Multhaup).

6THE ROLE OF IRON IN THE PATHOGENESIS OF PARKINSONS DISEASE (Manfred Gerlach, Kay L. Double, Mario E. Götz, Moussa B. H. Youdim, and Peter Riederer).

7IN VIVOASSESSMENT OF IRON IN HUNTINGTONS DISEASE AND OTHER AGE-RELATED NEURODEGENERATIVE BRAIN DISEASES (George Bartzokis, Po H. Lu, Todd A. Tishler, and Susan Perlman).

8COPPER-ZINC SUPEROXIDE DISMUTASE AND FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS (Lisa J. Whitson and P. John Hart).

9THE MALFUNCTIONING OF COPPER TRANSPORT IN WILSON AND MENKES DISEASES (Bibudhendra Sarkar).

10IRON AND ITS ROLE IN NEURODEGENERATIVE DISEASES (Roberta J. Ward and Robert R. Crichton).

11THE CHEMICAL INTERPLAY BETWEEN CATECHOLAMINES AND METAL IONS IN NEUROLOGICAL DISEASES (Wolfgang Linert, Guy N. L. Jameson, Reginald F. Jameson, and Kurt A. Jellinger).

12ZINC METALLONEUROCHEMISTRY: PHYSIOLOGY, PATHOLOGY, AND PROBES (Christopher J. Chang and Stephen J. Lippard).

13THE ROLE OF ALUMINUM IN NEUROTOXIC AND NEURODEGENERATIVE PROCESSES (Tamás Kiss, Krisztina Gajda-Schrantz, and Paolo F. Zatta).

14NEUROTOXICITY OF CADMIUM, LEAD, AND MERCURY (Hana R. Pohl, Henry G. Abadin, and John F. Risher).

15NEURODEGENERATIVE DISEASES AND METAL IONS. A CONCLUDING OVERVIEW (Dorothea Strozyk and Ashley I. Bush).

SUBJECT INDEX.

Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature ofBiological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., inBioinorganic Chemistry.

About this Book...

Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject.

Written by41 internationally recognized experts,Neurodegenerative Diseases and Metal Ions highlights, supported by130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized.

Helmut Sigel isEmeritus Professor (2003) of Inorganic Chemistry at the University of Basel, Switzerland, and a previous editor of theMIBS series until Volume 44. He serves on various editorial and advisory boards, published over 300 articles on metal ion complexes of nucleotides, coenzymes, and other biologically relevant ligands. He lectured worldwide and was namedProtagonist in Chemistry (2002) byICA (issue339). Among further honors are theP. Ray Award (Indian Chemical Society, of which he is also an Honorary Fellow), theWernerAward (Swiss Chemical Society), aDoctor of Science honoris causa degree (Kalyani University, India), appointments asVisiting Professor (e.g., Austria, China, UK) andEndowedLectureships.

Roland K. O. Sigel is Assistant Professor (2003) of Inorganic Chemistry at the University of Zürich, Switzerland, endowed with aFörderungsprofessur of the Swiss National Science Foundation. He received his doctoral degreesumma cum laude (1999) from the University of Dortmund, Germany, working with Bernhard Lippert; thereafter he spent nearly three years at Columbia University, New York, USA, in the group of Anna Marie Pyle (now Yale University); during the six years abroad he received several fellowships from various sources. His research focuses on the structural and catalytic role of metal ions in ribozymes, especially group II introns, and on related topics. He was also an editor of Volumes 43 and 44 of theMIBS series.