Transplantation of Composite Tissue Allografts (eBook) von Charles W. Hewitt

Section I.- The Establishment of Composite Tissue Allotransplantion as a Clinical Reality.- The Evolution of Composite Tissue Allotransplantation: the Twentieth Century Realization of Cosmas and Damian.- The Impact of the Discovery of Cyclosporine on Transplantation of Composite Tissue Allografts.- The First Limb Transplants with Cyclosporine.- Section II.- Translational Research in Composite Tissue Allotransplantation.- Relative Antigenicity of Allograft Components and Differential Rejection.- On the Road to Tolerance Induction in Composite Tissue Allotransplantation.- Donor-Specific Tolerance.- Immune Tolerance Induction: Basic Concepts for Composite Tissue Allotransplantation.- Section III.- Allograft Survival with Calcineurin Inhibitors.- Long-Term Prevention of Rejection and Combination Drug Therapy.- Locoregional Immunosuppression in Composite Tissue Allografting.- New Approaches to Antibody Therapy.- Section IV.- World Experience of Hand Transplantation-Independent Assessment.- Hand Transplantation: Lyon Experience.- Hand Transplantation: The Louisville Experience.- Hand Transplantation: The Innsbruck Experience.- Section V.- Vascularized Bone Marrow Transplantation.- Vascularized Bone Marrow Transplantation: Pathology of Composite Tissue Transplantation-Induced Graft-Versus-Host-Disease.- Immune Cell Redistribution After Vascularized Bone Marrow Transplantation.- Section VI.- Vascularized Knee Transplantation.- Tracheal Transplantation.- Laryngeal Transplantation.- Face Transplantation.- The Role of Allografts in Lower Extremity Reconstruction.- Skin Allografts in Scalp Reconstruction.- Abdominal Wall Transplantation.- Peripheral Nerve Allotransplantation.- Live-Donor Nerve Transplantation.- Section VII.- Ethical and Policy Concerns of Hand/Face Transplantation.- Ethical Debate on Human Face Transplantation.- Psychosocial Issues in Composite Tissue Allotransplantation.- Composite Tissue Transplantation in the Twenty-First Century.

This brilliant synthesis summarizes all of the recent accomplishments as well as the ongoing research in the field of composite tissue transplantation. It includes sections on hand transplantation and vascularized bone marrow transplantation. The volume focuses on immunology and the biotechnology/bioengineering aspects of transplantation surgery, as those two areas have demonstrated the most growth within the last five years in terms of current research.